The Supreme Court has rejected an appeal by the parents of sick baby Charlie Gard, over plans to take him to the US for treatment.
Chris Gard and Connie Yates want 10-month-old Charlie, who suffers from a rare genetic condition and has brain damage, to undergo a therapy trial.
His mother broke down in tears and screamed as justices announced their decision and had to be led away from the court by lawyers.
The court said doctors should continue life support treatment for 24 hours to give the European Court of Human Rights chance to consider the case.
This breaking news story is being updated and more details will be published shortly. Please refresh the page for the fullest version.
If you want to receive Breaking News alerts via email, or on a smartphone or tablet via the BBC News App then details on how to do so are available on this help page. You can also follow @BBCBreaking on Twitter to get the latest alerts.